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   kontyce – October 8, 2020

   Hey guys, Dr. Ko here from Reset Ketamine in Palm Springs and wanted to share with you a few exercises that I have been studying from a branch of philosophy called Stoicism. The first one is called “The View From Above.” So for a moment picture yourself where you’re sitting or standing right now and imagine as if you’re zooming out, and now you’re floating above your head and then going on even further you’re floating above the building that you’re in and then floating out you’re floating above the town or city that you live in and then floating above that you are now able to see the state or country that you’re in and then floating further out higher and higher until you can see the earth and then float out even further until Earth is just a speck of dust. Now, how do you feel? Pretty small, pretty minuscule, and that’s the point of this exercise. Sometimes when we are so sucked into our own situation and our own state, we forget that we are simply one out of 7.5 billion people in the world and we’re just one planet amongst many galaxies and universes that exists out there. And it’s nice to have a different perspective that’s so focused on me and my own little world and then shift and expand outward into more a global or universal picture. The second exercise is the exercise of setting expectations for the day. And there’s a quote by Marcus Aurelius and I want to read that quote to you, “The people I deal with today will be meddling, ungrateful, arrogant, dishonest, jealous, and surly. They are like this because they can’t tell good from evil. But I have seen the beauty of good and the ugliness of evil, and have recognized that the wrongdoer has a nature related to my own.” So Marcus Aurelius is saying to us that when we go out there and face the world expecting the worst ungrateful, meddling, jealous, all sorts of people and expect that as the given and the way that the natural way of the world is, that we’re not going to have these such high expectations for other people. And so if someone does something to disappoint us, it’s not gonna impact us as greatly and also he mentions this because he to himself has been all of these negative characteristics that he applies to other people. And you and I both know that there have been times when we’ve been ungrateful or jealous or meddling in other people’s affairs and so we to have that within our own nature and once we recognize that it’s common in other people and it’s also inherent within us, when things don’t go out the way we wanted to or the interactions don’t work out the way we wanted to we can just say hey maybe this is just the natural way of a human being. The third exercise that I want to share with you about stoicism is about “Negative Visualization”. So there’s a lot of talk out there these days about positive visualization, like seeing the positive the best outcomes and I like that and I agree with that but sometimes it’s also good to use the opposite of this negative and visualization. And so what I mean by this is imagining the worst-case scenario of something that might happen. For example, you can say, “Hey my dog got run over by a car,” and just picture that for a moment. “Oh my god my poor dog he got run over and now he’s at the vet he may not make it. I might have to put him down.” if you think about these negative things that could happen it’s going to make me appreciate much more of what I currently have. And so when we get used to certain things whether that’s the nice car, the house, the running water, air conditioning we have this hedonic treadmill of adaptation that occurs which is natural. So you’ll buy the iPhone 10 and you love it. You’re like, “Wow this is so cool I got the iPhone 10,” and then two or three months later it just becomes another phone. Until the iPhone 11 comes out and you’re like, “Oh my god I want the iPhone 11.” You love it and then you get the iPhone 11 and then a couple months later you become used to it. So it’s important to visualize briefly 1 to 2 times 3 times per week, just kind of the negative things that could happen in your life whether that’s losing your job, losing your spouse, losing a limb, losing your vision. Something that’s like, “Oh my god if that happened it would be so terrible” because when we do this it’ll help us appreciate what we currently have and this is the antidote to that hedonic treadmill, “Negative Visualization.” So to summarize there are three stoic exercises: #1 “The View From Above” #2 Setting the expectations, and #3 “Negative Visualization.” So in addition to ketamine infusions, by simply switching your mindset and using these little tools it can definitely add to your mental health and it’s just a nice tool to have in your back pocket as we face our challenges of depression, anxiety, or PTSD. I know it helps me a lot. So please let me know what you think about this and leave me a message or comment below.

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   Ketherine h. – May 21, 2021

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   Ketamine History – October 30, 2021

   Ketamine’s history begins with phencyclidine, which was first synthesized in 1956 by chemists at Parke Davis Company (Maddox et al., 1965) who discovered ketamine’s unique and fascinating pharmacology.
   Phencyclidine was capable of causing the appearance of drunkenness in rodents, delirium in dogs, cataleptoid states in pigeons, and anesthesia in monkeys (Domino and Luby, 2012). Although demonstrated to be a safe and reliable anesthetic in humans, it also caused an intense, prolonged emergence delirium that ultimately made it undesirable for human use (Greifenstein et al., 1958; Johnstone et al., 1959; Domino and Luby, 2012).

   Efforts were subsequently redirected towards synthesizing shorter-acting analogs of phencyclidine that would have similar anesthetic potential but cause less emergence delirium. Ketamine, then identified as CI-581, was one such agent developed by Parke Davis consultant and organic chemist Calvin Stevens in 1962 (Domino, 1980). A structural analog at one-tenth the potency of its parent drug phencyclidine, ketamine was subsequently selected for human trials, and the first human anesthetic dose was administered on August 3, 1964 by two University of Michigan professors: Dr. Edward Domino of Pharmacology (Figure 1) and Dr. Guenter Corssen of Anesthesiology. In their initial pharmacological study of ketamine in 20 humans, Domino and Corssen found evidence that the drug could be safe and effective for clinical anesthetic use (Domino et al., 1965). In 1966, they published findings from the first clinical experiences with ketamine, reporting its anesthetic effects in 130 patients, aged 6 weeks to 86 years, undergoing a total of 133 surgical procedures (Corssen and Domino, 1966). They found that ketamine could rapidly produce profound analgesia with a unique state of altered consciousness and a limited duration of effect that could be safely prolonged with repeated administration. They also reported minimal side effects and a lack of severe emergence delirium compared to phencyclidine (Corssen and Domino, 1966). Ketalar (1970) became the first preparation of ketamine approved by the food and drug administration (FDA) for human use.

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